Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Hauptverfasser: Fatima Amin Adamude (Verfasst von), Ikenna Nnamdi Ezeaku (Verfasst von), Abraham Ehinomhen Ubhenin (Verfasst von), Ifeanyi Peter Onyeka (Verfasst von), Ahmad Adamu Ambi (Verfasst von), Ikechukwu Robert Uroko (Verfasst von), Emeka John Dingwoke (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2022-08-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...