Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Päätekijät: Fatima Amin Adamude (Tekijä), Ikenna Nnamdi Ezeaku (Tekijä), Abraham Ehinomhen Ubhenin (Tekijä), Ifeanyi Peter Onyeka (Tekijä), Ahmad Adamu Ambi (Tekijä), Ikechukwu Robert Uroko (Tekijä), Emeka John Dingwoke (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2022-08-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...