Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...

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Autori principali: Fatima Amin Adamude (Autore), Ikenna Nnamdi Ezeaku (Autore), Abraham Ehinomhen Ubhenin (Autore), Ifeanyi Peter Onyeka (Autore), Ahmad Adamu Ambi (Autore), Ikechukwu Robert Uroko (Autore), Emeka John Dingwoke (Autore)
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Pubblicazione: Elsevier, 2022-08-01T00:00:00Z.
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