Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• 主要な著者: Fatima Amin Adamude (著者), Ikenna Nnamdi Ezeaku (著者), Abraham Ehinomhen Ubhenin (著者), Ifeanyi Peter Onyeka (著者), Ahmad Adamu Ambi (著者), Ikechukwu Robert Uroko (著者), Emeka John Dingwoke (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2022-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...