Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Ngā kaituhi matua: Fatima Amin Adamude (Author), Ikenna Nnamdi Ezeaku (Author), Abraham Ehinomhen Ubhenin (Author), Ifeanyi Peter Onyeka (Author), Ahmad Adamu Ambi (Author), Ikechukwu Robert Uroko (Author), Emeka John Dingwoke (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2022-08-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...