Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Principais autores: Fatima Amin Adamude (Autor), Ikenna Nnamdi Ezeaku (Autor), Abraham Ehinomhen Ubhenin (Autor), Ifeanyi Peter Onyeka (Autor), Ahmad Adamu Ambi (Autor), Ikechukwu Robert Uroko (Autor), Emeka John Dingwoke (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2022-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...