Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Váldodahkkit: Fatima Amin Adamude (Dahkki), Ikenna Nnamdi Ezeaku (Dahkki), Abraham Ehinomhen Ubhenin (Dahkki), Ifeanyi Peter Onyeka (Dahkki), Ahmad Adamu Ambi (Dahkki), Ikechukwu Robert Uroko (Dahkki), Emeka John Dingwoke (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2022-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...