Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Những tác giả chính: Fatima Amin Adamude (Tác giả), Ikenna Nnamdi Ezeaku (Tác giả), Abraham Ehinomhen Ubhenin (Tác giả), Ifeanyi Peter Onyeka (Tác giả), Ahmad Adamu Ambi (Tác giả), Ikechukwu Robert Uroko (Tác giả), Emeka John Dingwoke (Tác giả)
• Định dạng: Sách
• Được phát hành: Elsevier, 2022-08-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...