Memantine: Reality and Potentiality
Memantine protects cultured neurons from excitotoxin-induced cell-death; it attenuated loss of cholinergic neurons in the CNS induced by injection of NMDA into the basal forebrain of rats. It has been shown that memantine induced production of brain-derived neurotrophic factor (BDNF), a substance sh...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
AboutScience Srl,
2008-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Memantine protects cultured neurons from excitotoxin-induced cell-death; it attenuated loss of cholinergic neurons in the CNS induced by injection of NMDA into the basal forebrain of rats. It has been shown that memantine induced production of brain-derived neurotrophic factor (BDNF), a substance shown to promote survival and differentiation of CNS neuron. Due to the preclinical effects of memantine owing to its anti-ischemic and anti-excitotoxic properties, recent clinical efficacy has been demonstrated in patients with advanced dementia of vascular origins. Therefore, it has been employed in different trials, in vascular dementia, showing a potential benefit and no unbearable side effects. Different studies underline the possible role of memantine in Parkinson Disease. |
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| Item Description: | 1177-3928 10.4137/DTI.S622 |