Study of the pharmacokinetics of antituberculosis drug Biomairin
Resume. The results of a studying the pharmacokinetics of the anti-tuberculosis drug Biomayrin in experimental animals (rats) after oral administration were presented. A comparative analysis of the pharmacokinetic parameters of Biomayrin with a comparing drug (a mixture of rifampicin, ethambutol and...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
LLC "Publisher OKI",
2018-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Resume. The results of a studying the pharmacokinetics of the anti-tuberculosis drug Biomayrin in experimental animals (rats) after oral administration were presented. A comparative analysis of the pharmacokinetic parameters of Biomayrin with a comparing drug (a mixture of rifampicin, ethambutol and isoniazid) showed that the bioavailability of isoniazid increased four times as a part of Biomayrin, the ethambutol and rifampicin three times compared to the comparing drug, thereby showing a prolonged effect. It should also be noted that the introduction of isoniazid into the polysaccharide matrix retards its metabolism to the therapeutically inactive acetylisoniazid. |
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| Item Description: | 2587-7836 2686-8830 10.24411/2587-7836-2018-10030 |