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Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation

Bcr-Abl threonine 315 to isoleucine 315 (T315I) gatekeeper mutation induced drug resistance remains an unmet clinical challenge for the treatment of chronic myeloid leukemia (CML). Chemical degradation of Bcr-AblT315I protein has become a potential strategy to overcome drug resistance. Herein, we fi...

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Main Authors: Liang Jiang (Author), Yuting Wang (Author), Qian Li (Author), Zhengchao Tu (Author), Sihua Zhu (Author), Sanfang Tu (Author), Zhang Zhang (Author), Ke Ding (Author), Xiaoyun Lu (Author)
Format: Book
Published: Elsevier, 2021-05-01T00:00:00Z.
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