Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population

• Main Authors: Sima SABBAGH (Author), Zakiye NADEALI (Author), Leila DEHGHANI (Author), Vahid SHAYGANNEJAD (Author), Majid REZVANI (Author), Masih SABOORI (Author), Hamid GANJI (Author), Soheil TAHANI (Author), Farzaneh DEHGHANI (Author), Saman HOSSEINZADEH (Author), Elnaz MARZBANI (Author), Peiman SHAFIEI (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C−1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS patients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017.  Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of −90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.

Item Description

10.18502/ijph.v48i9.3030
2251-6085
2251-6093