The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma via the Noncanonical Hedgehog Signaling Pathway

• Glavni autori: Ming Ji (Autor), Zhihui Zhang (Autor), Songwen Lin (Autor), Chunyang Wang (Autor), Jing Jin (Autor), Nina Xue (Autor), Heng Xu (Autor), Xiaoguang Chen (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system. Temozolomide (TMZ)-based adjuvant treatment has improved overall survival, but clinical outcomes remain poor; TMZ resistance is one of the main reasons for this. Here, we report a new phosphatidylinositid...