Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ

• Main Authors: Ya-Di Zhu (Author), Xiao-Qing Guan (Author), Jing Chen (Author), Sheng Peng (Author), Moshe Finel (Author), Ying-Yuan Zhao (Author), Rui-Min Wang (Author), Hui-Chang Bi (Author), Ming Lei (Author), Dan-Dan Wang (Author), Guang-Bo Ge (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

UDP-glucuronosyltransferase 1A1 (UGT1A1) is an essential enzyme in mammals that is responsible for detoxification and metabolic clearance of the endogenous toxin bilirubin and a variety of xenobiotics, including some crucial therapeutic drugs. Discovery of potent and safe UGT1A1 inducers will provid...