Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin-A levels but no association with fetuin-A polymorphisms
ABSTRACT: Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus. Thus, we aimed to investigate a possible relationship between fetuin-A gene polymorphism and the presence of dental calculus. A possibl...
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_5a1ff5a1d2f74d1c9608f6cd92a62fb0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Gülnihal Emrem DOĞAN |e author |
| 700 | 1 | 0 | |a Turgut DEMİR |e author |
| 700 | 1 | 0 | |a Esra LALOĞLU |e author |
| 700 | 1 | 0 | |a Ebru SAĞLAM |e author |
| 700 | 1 | 0 | |a Hülya AKSOY |e author |
| 700 | 1 | 0 | |a Abdulkadir YILDIRIM |e author |
| 700 | 1 | 0 | |a Fatih AKÇAY |e author |
| 245 | 0 | 0 | |a Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin-A levels but no association with fetuin-A polymorphisms |
| 260 | |b Sociedade Brasileira de Pesquisa Odontológica. | ||
| 500 | |a 1807-3107 | ||
| 500 | |a 10.1590/1807-3107bor-2016.vol30.0129 | ||
| 520 | |a ABSTRACT: Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus. Thus, we aimed to investigate a possible relationship between fetuin-A gene polymorphism and the presence of dental calculus. A possible relationship between serum, saliva and gingival crevicular fluid (GCF) levels of fetuin-A was also investigated. Fetuin-A c.742C > T and c.766C > G polymorphisms were investigated in 103 patients with or without dental calculus. Additionally, serum, saliva and GCF fetuin-A levels of patients were compared according to dental calculus presence. A significant difference was not observed in the distribution of the fetuin-A c.742C > T and c.766C > G polymorphisms between patients with or without dental calculus. Saliva and GCF fetuin-A concentrations of patients with dental calculus were statistically higher than those without dental calculus (P=0.001, P=0.036 respectively). According to our results, fetuin-A c.742C > T and c.766C > G polymorphisms were not associated with presence of dental calculus. However, higher GCF and saliva fetuin-A levels were detected in patients with dental calculus than in patients without dental calculus, which may result from an adaptive mechanism to inhibit mineral precipitation and eventually calculus formation. | ||
| 546 | |a EN | ||
| 690 | |a Polymorphism, Genetic | ||
| 690 | |a Alpha-2-HS-Glycoprotein | ||
| 690 | |a Saliva | ||
| 690 | |a Gingival Crevicular Fluid | ||
| 690 | |a Dental Calculus | ||
| 690 | |a Dentistry | ||
| 690 | |a RK1-715 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Brazilian Oral Research, Vol 30, Iss 1 | |
| 787 | 0 | |n http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242016000100320&lng=en&tlng=en | |
| 787 | 0 | |n https://doaj.org/toc/1807-3107 | |
| 856 | 4 | 1 | |u https://doaj.org/article/5a1ff5a1d2f74d1c9608f6cd92a62fb0 |z Connect to this object online. |