Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study
Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction. Objective: We aimed to investigate the underlying mechanisms of the leptin-resistance, ev...
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Shahid Sadoughi University of Medical Sciences,
2018-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_5a21243c1b4b4b5d91d18c30bccdc9e4 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Pedro Gonzalez-Añover |e author |
| 700 | 1 | 0 | |a Laura Torres-Rovira |e author |
| 700 | 1 | 0 | |a Consolacion García-Contreras |e author |
| 700 | 1 | 0 | |a Marta Vazquez-Gomez |e author |
| 700 | 1 | 0 | |a Jose Luis Pesantez |e author |
| 700 | 1 | 0 | |a Maria Victoria Sanz-Fernandez |e author |
| 700 | 1 | 0 | |a Susana Astiz |e author |
| 700 | 1 | 0 | |a Antonio Gonzalez-Bulnes |e author |
| 245 | 0 | 0 | |a Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study |
| 260 | |b Shahid Sadoughi University of Medical Sciences, |c 2018-08-01T00:00:00Z. | ||
| 500 | |a 2476-4108 | ||
| 500 | |a 2476-3772 | ||
| 520 | |a Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction. Objective: We aimed to investigate the underlying mechanisms of the leptin-resistance, evaluating the antioxidant homeostasis of leptin-resistant and lean swine fetuses. Materials and Methods: The study included 70 plasma samples from fetuses at day 62 of gestation (mid-pregnancy), from breeds with (Iberian breed; n=35) and without leptin resistance (25% Large White x 25% Landrace x 50% Pietrain; n=35). The antioxidant status of the plasma samples was determined by photoinduced chemiluminescence whilst systemic oxidative stress was assessed determining plasma hydrogen peroxide concentration by enzimoimmunoassay. Results: Plasma total antioxidant capacity was significantly lower in leptin-resistant fetuses (p=0.003), whilst systemic oxidative stress was increased (p=0.02). Conclusion: Our results indicate key differences in the antioxidant status in pregnancies affected by leptin resistance | ||
| 546 | |a EN | ||
| 690 | |a Animal models | ||
| 690 | |a Fetus | ||
| 690 | |a Leptin | ||
| 690 | |a Oxidative stress | ||
| 690 | |a Pregnancy | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 690 | |a Reproduction | ||
| 690 | |a QH471-489 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n International Journal of Reproductive BioMedicine, Vol 16, Iss 8, Pp 497-500 (2018) | |
| 787 | 0 | |n http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-598&slc_lang=en&sid=1 | |
| 787 | 0 | |n https://doaj.org/toc/2476-4108 | |
| 787 | 0 | |n https://doaj.org/toc/2476-3772 | |
| 856 | 4 | 1 | |u https://doaj.org/article/5a21243c1b4b4b5d91d18c30bccdc9e4 |z Connect to this object online. |