Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers.

• Principais autores: Kamrul Islam (Autor), Motaher Hossain (Autor), Meagan Kelly (Autor), Leslie M Mayo Smith (Autor), Richelle C Charles (Autor), Taufiqur Rahman Bhuiyan (Autor), Pavol Kováč (Autor), Peng Xu (Autor), Regina C LaRocque (Autor), Stephen B Calderwood (Autor), Jakub K Simon (Autor), Wilbur H Chen (Autor), Douglas Haney (Autor), Michael Lock (Autor), Caroline E Lyon (Autor), Beth D Kirkpatrick (Autor), Mitchell Cohen (Autor), Myron M Levine (Autor), Marc Gurwith (Autor), Jason B Harris (Autor), Firdausi Qadri (Autor), Edward T Ryan (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BACKGROUND:Cholera is an acute voluminous dehydrating diarrheal disease caused by toxigenic strains of Vibrio cholerae O1 and occasionally O139. A growing body of evidence indicates that immune responses targeting the O-specific polysaccharide (OSP) of V. cholerae are involved in mediating protectio...