Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers.

• Main Authors: Kamrul Islam (Author), Motaher Hossain (Author), Meagan Kelly (Author), Leslie M Mayo Smith (Author), Richelle C Charles (Author), Taufiqur Rahman Bhuiyan (Author), Pavol Kováč (Author), Peng Xu (Author), Regina C LaRocque (Author), Stephen B Calderwood (Author), Jakub K Simon (Author), Wilbur H Chen (Author), Douglas Haney (Author), Michael Lock (Author), Caroline E Lyon (Author), Beth D Kirkpatrick (Author), Mitchell Cohen (Author), Myron M Levine (Author), Marc Gurwith (Author), Jason B Harris (Author), Firdausi Qadri (Author), Edward T Ryan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Cholera is an acute voluminous dehydrating diarrheal disease caused by toxigenic strains of Vibrio cholerae O1 and occasionally O139. A growing body of evidence indicates that immune responses targeting the O-specific polysaccharide (OSP) of V. cholerae are involved in mediating protectio...