Fluorescence Cross-Correlation Spectroscopy Yields True Affinity and Binding Kinetics of <i>Plasmodium</i> Lactate Transport Inhibitors
Blocking lactate export in the parasitic protozoan <i>Plasmodium falciparum</i> is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites in culture. The pentafluoro-3-hydroxy-pent-2-en-1...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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MDPI AG,
2021-08-01T00:00:00Z.
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