Antidepressant-like effect of aqueous extract from Rosa damascena in mice
Objective: Rosa damascena mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming...
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| Main Authors: | , , |
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| Format: | Book |
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Mashhad University of Medical Sciences,
2011-09-01T00:00:00Z.
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| Summary: | Objective: Rosa damascena mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming test (FST). Material and Methods: Three doses of aqueous extract (15, 60 and 90 mg/kg) was injected intraperitoneally. After 30 min of injection, immobility and swimming times were measured and compared with control (negative control) and imipramine (positive control). Results: The results showed that low dose (15mg/kg) of extract significantly increased swimming time and decreased immobility time. However, the two high doses of extract (60 and 90mg/kg) had no significant effect on these parameters. Conclusion: These results proposed antidepressant-like effect of low concentration of aqueous extract of R. damascena. |
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| Item Description: | 2228-7930 2228-7949 |