Application of a high‐resolution in vitro human MDR1‐MDCK assay and in vivo studies in preclinical species to improve prediction of CNS drug penetration

• Автори: Licong Jiang (Автор), Sanjeev Kumar (Автор), Marc Nuechterlein (Автор), Marissa Reyes (Автор), Dao Tran (Автор), Clifford Cabebe (Автор), Peggy Chiang (Автор), James Reynolds (Автор), Scott Carrier (Автор), Yongkai Sun (Автор), Peter Eddershaw (Автор), Tanya Hay (Автор), Weichao Chen (Автор), Bo Feng (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2022-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract P‐glycoprotein (P‐gp, MDR1) is expressed at the blood-brain barrier (BBB) and restricts penetration of its substrates into the central nervous system (CNS). In vitro MDR1 assays are frequently used to predict the in vivo relevance of MDR1‐mediated efflux at the BBB. It has been well establi...