Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea
Mast cell (MC) activation triggered by immunoglobulin E (IgE)-antigen crosslinking involves intracellular Ca2+ influx through the ORAI1 channel, which precedes granule exteriorization and de novo synthesis of mediators. Pharmacologically suppressing MCs via the inhibition of the ORAI1 Ca2+ channel m...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2023-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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