Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles

Yong-liang Zhu, Shuang-long Li, Ke-li Chen, Kun-peng Ma, De-qian Wu, Xiang-jun Qiu Medical College of Henan University of Science and Technology, Luoyang 471023, People’s Republic of ChinaCorrespondence: Xiang-jun QiuMedical College of Henan University of Science and Technology, Luoyang 47...

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Main Authors: Zhu Y (Author), Li S (Author), Chen K (Author), Ma K (Author), Wu D (Author), Qiu X (Author)
Format: Book
Published: Dove Medical Press, 2019-09-01T00:00:00Z.
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100 1 0 |a Zhu Y  |e author 
700 1 0 |a Li S  |e author 
700 1 0 |a Chen K  |e author 
700 1 0 |a Ma K  |e author 
700 1 0 |a Wu D  |e author 
700 1 0 |a Qiu X  |e author 
245 0 0 |a Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles 
260 |b Dove Medical Press,   |c 2019-09-01T00:00:00Z. 
500 |a 1177-8881 
520 |a Yong-liang Zhu, Shuang-long Li, Ke-li Chen, Kun-peng Ma, De-qian Wu, Xiang-jun Qiu Medical College of Henan University of Science and Technology, Luoyang 471023, People’s Republic of ChinaCorrespondence: Xiang-jun QiuMedical College of Henan University of Science and Technology, Luoyang 471023, People’s Republic of ChinaEmail lyxiangjun@126.comObjective: To investigate the effects of Chinese herb Danzhi Xiaoyao pills on the pharmacokinetics of venlafaxine and its metabolites O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) in beagles by using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).Methods: Six beagles (half male, half female) were chosen to test, being fasted before the experiment but having free access to drinking water 1 day before being fed drugs. After oral administration of venlafaxine hydrochloride tablets (10.28 mg/kg), the blood samples were collected in succession at different points in time. After 1-week washout period, Danzhi Xiaoyao pills (0.6g/kg) were given through oral administration to the six beagles every morning until the 7th day, venlafaxine hydrochloride tablets (10.28 mg/kg) were given after feeding Danzhi Xiaoyao pills (0.6g/kg) half an hour and blood samples were collected continuously at different points. All samples were analyzed by UPLC-MS/MS, and the main pharmacokinetic parameters of venlafaxine, ODV and NDV were computed by DAS 2.0.Results: The Cmax of the venlafaxine group (control group) and the combination group (experimental group) were (2267.26±252.89) ng/mL and (1542.64±190.73) ng/mL, respectively. The AUC(0-∞) of the two groups were (13,934.79±3609.23) ng·h/mL and (8001.91±2167.58) ng·h/mL, respectively. The ODV Cmax of the two groups were (2253.80±215.81) ng/mL and (2721.37±118.20) ng/mL, and AUC(0-∞) were (13,974.99±2784.04) ng·h/mL and (17,539.44±1894.29) ng·h/mL, respectively. The NDV Cmax of the two groups were (50.98±5.76) ng/mL and (58.74±12.33) ng/mL, and AUC(0-∞) were (179.26±34.94) ng·h/mL and (220.68±51.41) ng·h/mL, respectively. After administration of Danzhi Xiaoyao pills, the Cmax and AUC(0-∞) of venlafaxine decreased significantly, indicating that the plasma exposure of venlafaxine decreased. The increase of Cmax and AUC(0-∞) of ODV and NDV indicated a rise in plasma exposure.Conclusion: Danzhi Xiaoyao pills can accelerate the metabolism of venlafaxine in beagles. In clinical, when venlafaxine was co-administrated with Danzhi Xiaoyao pills, dose adjustment of venlafaxine should be taken into account.Keywords: beagle, UPLC-MS/MS, Danzhi Xiaoyao pills, venlafaxine, ODV, NDV, drug–drug interaction 
546 |a EN 
690 |a Beagle 
690 |a UPLC-MS/MS 
690 |a Danzhi Xiaoyao Pills 
690 |a Venlafaxine 
690 |a ODV 
690 |a NDV 
690 |a Drug-drug interaction 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Drug Design, Development and Therapy, Vol Volume 13, Pp 3343-3355 (2019) 
787 0 |n https://www.dovepress.com/effect-of-chinese-herb-danzhi-xiaoyao-pills-on-pharmacokinetics-of-ven-peer-reviewed-article-DDDT 
787 0 |n https://doaj.org/toc/1177-8881 
856 4 1 |u https://doaj.org/article/5b03d9d1a7f74c0fbbb845e4e694574a  |z Connect to this object online.