Sigma 1 Receptor Co-Localizes with NRF2 in Retinal Photoreceptor Cells

• Main Authors: Shannon R. Barwick (Author), Mevish S. Siddiq (Author), Jing Wang (Author), Haiyan Xiao (Author), Brendan Marshall (Author), Elizabeth Perry (Author), Sylvia B. Smith (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-06-01T00:00:00Z.
• Fag: article
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Sigma 1 receptor (Sig1R), a modulator of cell survival, has emerged as a novel target for retinal degenerative disease. Studies have shown that activation of Sig1R, using the high affinity ligand (+)-pentazocine ((+)-PTZ), improves cone function in a severe retinopathy model. The rescue is accompani...