Phenethylisothiocyanate Potentiates Platinum Therapy by Reversing Cisplatin Resistance in Cervical Cancer

• Prif Awduron: Elizabeth Mahapatra (Awdur), Debomita Sengupta (Awdur), Ravindra Kumar (Awdur), Budheswar Dehury (Awdur), Salini Das (Awdur), Madhumita Roy (Awdur), Sutapa Mukherjee (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Acquired cisplatin resistance in cervical cancer therapy is principally caused by reduction in intracellular drug accumulation, which is exerted by hyperactivation of the oncogenic PI3K/Akt signaling axis and overexpression of cisplatin-exporter MRP2 along with prosurvival effectors NF-κB and IAPs i...