MnTnHex-2-PyP<sup>5+</sup>, Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways
Tumor migration and invasion induced by the epithelial-to-mesenchymal transition (EMT) are prerequisites for metastasis. Here, we investigated the inhibitory effect of a mimic of superoxide dismutase (SOD), cationic Mn(III) <i>ortho</i>-substituted <i>N</i>-n-hexylpyridylporp...
Saved in:
Main Authors: | Sung-Won Shin (Author), Changhoon Choi (Author), Hakyoung Kim (Author), Yeeun Kim (Author), Sohee Park (Author), Shin-Yeong Kim (Author), Ines Batinic-Haberle (Author), Won Park (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2021-11-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The SOD Mimic MnTnHex-2-PyP<sup>5+</sup> Reduces the Viability and Migration of 786-O Human Renal Cancer Cells
by: João G. Costa, et al.
Published: (2019) -
MnTnHex-2-PyP<sup>5+</sup> Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells
by: Rita B. Soares, et al.
Published: (2022) -
Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP<sup>4+</sup>, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H<sub>2</sub>O)MnTnHex-2-PyP<sup>5+</sup>
by: Litao Li, et al.
Published: (2020) -
Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP<sup>5+</sup> (BMX-001)
by: Sun Up Noh, et al.
Published: (2024) -
Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation
by: John Mark Cline, et al.
Published: (2018)