Pathophysiology of Atopic Dermatitis and Psoriasis: Implications for Management in Children

• Main Authors: Raj Chovatiya (Author), Jonathan I. Silverberg (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2227-9067; 10.3390/children6100108
• Keywords: atopic dermatitis; psoriasis; inflammation; cytokine; skin-barrier; topical therapy; systemic therapy; biologic therapy; Pediatrics; RJ1-570
• Source: Children, Vol 6, Iss 10, p 108 (2019)

Atopic dermatitis (AD) and psoriasis are chronic inflammatory skin diseases associated with a significant cutaneous and systemic burden of disease as well as a poor health-related quality of life. Here, we review the complex pathophysiology of both AD and psoriasis and discuss the implications for treatment with current state-of-the-art and emerging topical and systemic therapies. Both AD and psoriasis are caused by a complex combination of immune dysregulation, skin-barrier disruption, genetic factors, and environmental influences. Previous treatments for both diseases were limited to anti-inflammatory agents that broadly suppress inflammation. Emerging insights into relevant pathways, including recognition of the role of T-helper type 2 driven inflammation in AD and T-helper 1 and 17 driven inflammation in psoriasis, have led to a therapeutic revolution. There are a number of novel treatment options available for AD and psoriasis with many more currently under investigation.