Lung metastasis of endometrioid carcinoma aberrantly expressing thyroid transcription factor-1
It is known that thyroid transcription factor-1(TTF-1) is expressed in a small percentage of primary gynecological adenocarcinomas, including endometrial cancers. However, this is the first time this phenomenon has been reported that metastatic endometrioid carcinoma (EC) was induced TTF-1 by pulmon...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2020-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | It is known that thyroid transcription factor-1(TTF-1) is expressed in a small percentage of primary gynecological adenocarcinomas, including endometrial cancers. However, this is the first time this phenomenon has been reported that metastatic endometrioid carcinoma (EC) was induced TTF-1 by pulmonary niche. An 80'syear-old female patient, nonsmoker was addressed to our institution for the 14 mm solitary mass of the right lower lung. This tumor was negative for TTF-1. She had a previous history of grade2 EC of the uterine corpus. Chest computed tomography showed a 19 × 10 × 8- mm well-circumscribed lobular non-necrotizing mass. Right lower wedge resection was performed. Immunohistochemical findings showed that 20% of the neoplastic cells expressed TTF-1. In the present case, TTF-1 was expressed in the lung metastasis, but not in the primary EC of the uterus. Some lung factors might have induced TTF-1 in metastatic EC cells. The fact that TTF-1-positive cancer cells were located just adjacent to lung parenchyma suggests the influence of certain lung factors. |
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| Item Description: | 2214-3300 10.1016/j.ehpc.2020.200448 |