Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model

• Главные авторы: Karina Spunde (Автор), Brigita Vigante (Автор), Unda Nelda Dubova (Автор), Anda Sipola (Автор), Irena Timofejeva (Автор), Anna Zajakina (Автор), Juris Jansons (Автор), Aiva Plotniece (Автор), Karlis Pajuste (Автор), Arkadij Sobolev (Автор), Ruslan Muhamadejev (Автор), Kristaps Jaudzems (Автор), Gunars Duburs (Автор), Tatjana Kozlovska (Автор)
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• Опубликовано: MDPI AG, 2022-06-01T00:00:00Z.
• Предметы: article
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Capsid assembly modulators (CAMs) have emerged as a promising class of antiviral agents. We studied the effects of twenty-one newly designed and synthesized CAMs including heteroaryldihydropyrimidine compounds (HAPs), their analogs and standard compounds on hepatitis B virus (HBV) capsid assembly. C...