Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model

• Main Authors: Karina Spunde (Author), Brigita Vigante (Author), Unda Nelda Dubova (Author), Anda Sipola (Author), Irena Timofejeva (Author), Anna Zajakina (Author), Juris Jansons (Author), Aiva Plotniece (Author), Karlis Pajuste (Author), Arkadij Sobolev (Author), Ruslan Muhamadejev (Author), Kristaps Jaudzems (Author), Gunars Duburs (Author), Tatjana Kozlovska (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Capsid assembly modulators (CAMs) have emerged as a promising class of antiviral agents. We studied the effects of twenty-one newly designed and synthesized CAMs including heteroaryldihydropyrimidine compounds (HAPs), their analogs and standard compounds on hepatitis B virus (HBV) capsid assembly. C...