Formulation of Alpha Tocopherol Acetate as a Powder Dosage Form by Adsorption
Alpha-tocopherol acetate is one of the most important vitamin E derivatives,that were used as antioxidants. Adsorbents like kaolin, magnesium carbonate, and microcrystalline cellulose were used successfully to incorporate oily alpha-tocopherol acetate into an acceptable powder dosage form. The resu...
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College of Pharmacy University of Baghdad,
2017-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_5b87bc2fd0a54a1a94e8de6e0eec6d28 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Zena A. Abdulhameed |e author |
| 700 | 1 | 0 | |a Yehia I. Khalil |e author |
| 245 | 0 | 0 | |a Formulation of Alpha Tocopherol Acetate as a Powder Dosage Form by Adsorption |
| 260 | |b College of Pharmacy University of Baghdad, |c 2017-03-01T00:00:00Z. | ||
| 500 | |a 2521-3512 | ||
| 500 | |a 1683-3597 | ||
| 520 | |a Alpha-tocopherol acetate is one of the most important vitamin E derivatives,that were used as antioxidants. Adsorbents like kaolin, magnesium carbonate, and microcrystalline cellulose were used successfully to incorporate oily alpha-tocopherol acetate into an acceptable powder dosage form. The results revealed that microcrystalline cellulose as an adsorbents gave the best results with 50% loading capacity at time, 8 minutes before and after incubation period (3 months at 30C°), while kaolin and magnesium carbonate have been shown a significant difference before and after incubation. Addition of 1% w/w magnesium carbonate to the kaolin enhanced the loading capacity by decreasing the time of adsorption from 20 to 6 minutes and 47 to 9 minutes before and after incubation respectively. The study indicated that the best adsorbent to be used in case of oral vitamin E toxicity is microcrystalline cellulose while magnesium carbonate could be used in the formulation for their best adsorption effect. Key words : Adsorption , Tocopherol Acetate powder | ||
| 546 | |a EN | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Iraqi Journal of Pharmaceutical Sciences, Vol 16, Iss 1 (2017) | |
| 787 | 0 | |n https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/262 | |
| 787 | 0 | |n https://doaj.org/toc/2521-3512 | |
| 787 | 0 | |n https://doaj.org/toc/1683-3597 | |
| 856 | 4 | 1 | |u https://doaj.org/article/5b87bc2fd0a54a1a94e8de6e0eec6d28 |z Connect to this object online. |