Perkembangan Plasenta dan Pertumbuhan Janin pada Tikus Hamil yang Diinfeksi Porphyromonas Gingivalis Placental Development and Fetal Growth in Porphyromonas Gingivalis-Infected Pregnant Rats
Maternal Porphyromonasgingivalis infection on periodontal tissue can result in Porphyromonasgingivalis dissemination to umbillical cord. Porphyromonas gingivalis presumably gain access to the systemic circulation via local tissue inflammation, and may affect the placental development and the fetus i...
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| Format: | Book |
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Universitas Muhammadiyah Yogyakarta,
2014-01-01T00:00:00Z.
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| Summary: | Maternal Porphyromonasgingivalis infection on periodontal tissue can result in Porphyromonasgingivalis dissemination to umbillical cord. Porphyromonas gingivalis presumably gain access to the systemic circulation via local tissue inflammation, and may affect the placental development and the fetus itself. This study aimed to analize the effect of periodontal infection with Porphyromonas gingivalis on placental development, and to determine its effect on fetal growth in a pregnant rat model. Female rats were infected with live-Porphyromonas gingivalis at concentration of 2x109 cells/ml into subgingival sulcus of the maxillary first molar before and/or during pregnancy. They were sacrified on gestational day (GD) 20. Fetuses were evaluated for weight and length. All placentas were fixed in 10% buffered formalin, processed for paraffin embedding, and stained with hematoxylin and eosin.The histopathological analysis of placentas on GD 20 showed that trophoblast cells in labyrinth and junctional zone had a greater density in control group than Porphyromonas gingivalis-infected periodontal maternal group. The nucleated-erythrocytes were found more abundant in the fetal blood vessels of Porphyromonas gingivalis-infected periodontal maternal group than in the fetal blood vessels of control group. In conclusion, the impaired placental morphology influenced the normal function of placenta to maintain the growth and development of fetus. The decreased placental weightresulted in the decreased of fetal weight andlength. |
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| Item Description: | 2252-9764 2685-9165 10.18196/di.v3i1.1725 |