Mechanisms of CDK4/6 Inhibitor Resistance in Luminal Breast Cancer

• Main Authors: Zhen Li (Author), Wei Zou (Author), Ji Zhang (Author), Yunjiao Zhang (Author), Qi Xu (Author), Siyuan Li (Author), Ceshi Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a new-generation CDK inhibitor, a CDK4/6 inhibitor combined with endocrine therapy has been successful in the treatment of advanced estrogen receptor-positive (ER+) breast cancer. Although there has been overall progress in the treatment of cancer, drug resistance is an emerging cause for breast...