Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

• Glavni autori: Bin Yang (Autor), Vasily M. Gelfanov (Autor), Kimberley El (Autor), Alex Chen (Autor), Rebecca Rohlfs (Autor), Barent DuBois (Autor), Ann Maria Kruse Hansen (Autor), Diego Perez-Tilve (Autor), Patrick J. Knerr (Autor), David D'Alessio (Autor), Jonathan E. Campbell (Autor), Jonathan D. Douros (Autor), Brian Finan (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2022-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Objective: Glucose-dependent insulinotropic polypeptide (GIP) is one of the two major incretin factors that regulate metabolic homeostasis. Genetic ablation of its receptor (GIPR) in mice confers protection against diet-induced obesity (DIO), while GIPR neutralizing antibodies produce additive weigh...