Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is one of the two major incretin factors that regulate metabolic homeostasis. Genetic ablation of its receptor (GIPR) in mice confers protection against diet-induced obesity (DIO), while GIPR neutralizing antibodies produce additive weigh...
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Elsevier,
2022-12-01T00:00:00Z.
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