Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

• Main Authors: Bin Yang (Author), Vasily M. Gelfanov (Author), Kimberley El (Author), Alex Chen (Author), Rebecca Rohlfs (Author), Barent DuBois (Author), Ann Maria Kruse Hansen (Author), Diego Perez-Tilve (Author), Patrick J. Knerr (Author), David D'Alessio (Author), Jonathan E. Campbell (Author), Jonathan D. Douros (Author), Brian Finan (Author)
• 格式: 圖書
• 出版: Elsevier, 2022-12-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Objective: Glucose-dependent insulinotropic polypeptide (GIP) is one of the two major incretin factors that regulate metabolic homeostasis. Genetic ablation of its receptor (GIPR) in mice confers protection against diet-induced obesity (DIO), while GIPR neutralizing antibodies produce additive weigh...