Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran

• Main Authors: HR Honarmand (Author), SS Eshraghi (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2011-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: This study is performed to reveal most common species and subspecies of leptospires that are main causes of hu­man leptospirosis in Guilan, Northern Province of Iran. Methods: We performed IgM-ELISA and MAT on 282 blood samples from patients who attended to 3 hospitals in the flat area of Guilan Province with clinical symptoms consisted with leptospirosis.  All specimens with titers ≥ 160 against at least one pathogenic strain in MAT and with titers ≥160 in IgM-ELISA were regarded confirmed positive cases indicative acute dis­ease. For any confirmed positive cases, we determined the strains, which had the highest titer to determine the frequency of most common serovars and serogroups.  Results: Seventy of 282 sera had titers ≥160 against at least one pathogenic strain in MAT and titers ≥ 160 in IgM-ELISA. We determined frequency of common causative serogroups which had highest titers in 70 positive cases and only cases which had high titers in MAT and in IgM-ELISA were selected which is a reliable criterion to detect acute disease and to deter­mine causative serogroup. Conclusion: Nine serogroups including sejroe, grippotyphosa, mini, ictero haemorrhagiae, celledoni, autumnalis, cynopteri, pomona, and javanica were more responsible of acute leptospirosis in Guilan.

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2251-6085
2251-6093