Fully Automated, High-Dose Radiosynthesis of [¹⁸F]PARPi

• Main Authors: Anna Pacelli (Author), Fadi Zarrad (Author), Corentin Warnier (Author), Thibault Gendron (Author), Muhammad Otabashi (Author), Charles Vriamont (Author), Alex Jackson (Author), Wolfgang P. Fendler (Author), Ken Herrmann (Author), Michael Nader (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

[¹⁸F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit the starting activity. The automation of the previously reported protocol for [¹⁸F]PARPi synthesis is challenging, as it requires transferring microvolumes of reagents, which many platforms cannot accommodate. We report a revised, high yield, and automated protocol for the radiosynthesis of [¹⁸F]PARPi, with final doses of over 20 GBq.

Item Description

10.3390/ph15070865
1424-8247