Cover Image

Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways

Abstract Background Intervertebral disc degeneration (IVDD) is a common spine disease with inflammation as its main pathogenesis. Mulberroside A (MA), isolated from herbal medicine, possesses anti-inflammatory characteristics in many diseases. Whereas, there is little exploration of the therapeutic...

Full description

Saved in:

Bibliographic Details
Main Authors:	Tao Xu (Author), Hongqi Zhao (Author), Xuan Fang (Author), Shanxi Wang (Author), Jian Li (Author), Hua Wu (Author), Weihua Hu (Author), Rui Lu (Author)
Format:	Book
Published:	BMC, 2024-08-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NF-κB signaling pathway
by: Huan Yang, et al.
Published: (2022)

Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways
by: Li B, et al.
Published: (2022)

Impact of NF-κB pathway on the intervertebral disc inflammation and degeneration induced by over‐mechanical stretching stress
by: Hui Xu, et al.
Published: (2021)

Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling
by: Zhiqian Chen, et al.
Published: (2021)

Intervertebral disc degeneration and regenerative medicine
by: Mariam Farag, et al.
Published: (2024)

Retraction Note: Impact of NF-κB pathway on the intervertebral disc inflammation and degeneration induced by over-mechanical stretching stress
by: Hui Xu, et al.
Published: (2022)

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population
by: Sara Hanaei, et al.
Published: (2020)

Karacoline, identified by network pharmacology, reduces degradation of the extracellular matrix in intervertebral disc degeneration via the NF-κB signaling pathway
by: Xiaoli Zhou, et al.
Published: (2020)

Sirtuins in intervertebral disc degeneration: current understanding
by: Jianlin Shen, et al.
Published: (2024)

Bioenergetic dysfunction in the pathogenesis of intervertebral disc degeneration
by: Chao Song, et al.
Published: (2024)

Role of Autophagy and Pyroptosis in Intervertebral Disc Degeneration
by: Wang Z, et al.
Published: (2024)

Lumbar intervertebral disc degeneration in collegiate rowers
by: Chie Sekine, et al.
Published: (2014)

Investigating the therapeutic potential of hesperidin targeting CRISP2 in intervertebral disc degeneration and cancer risk mitigation
by: Hui Zhang, et al.
Published: (2024)

Intervertebral disc degeneration-Current therapeutic options and challenges
by: Ankita Samanta, et al.
Published: (2023)

INTERVERTEBRAL DISC DEGENERATION LINKED TO STRUCTURAL GENE VARIATIONS
by: Shahzad Shoukat Nayani, et al.
Published: (2024)

Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
by: Zhangfu Li, et al.
Published: (2023)

Degeneration and regeneration of the intervertebral disc: lessons from development
by: Lachlan J. Smith, et al.
Published: (2011)

Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFα/NFκB Pathway
by: Xiao Yang, et al.
Published: (2022)

Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling
by: Yun Teng, et al.
Published: (2023)

Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response
by: Zeng Q, et al.
Published: (2023)

Natural products can modulate inflammation in intervertebral disc degeneration
by: Zongtai Liu, et al.
Published: (2023)

Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering
by: Yifan Wang, et al.
Published: (2024)

Stem Cell Therapy and Exercise for Treatment of Intervertebral Disc Degeneration
by: Bo Li, et al.
Published: (2021)

Mesenchymal Stem Cell for Prevention and Management of Intervertebral Disc Degeneration
by: Umile Giuseppe Longo, et al.
Published: (2012)

Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications
by: Ge Y, et al.
Published: (2022)

Unveiling the Gut-Disc Axis: How Microbiome Dysbiosis Accelerates Intervertebral Disc Degeneration
by: Sun Y, et al.
Published: (2024)

Andrographolide Inhibits Static Mechanical Pressure-Induced Intervertebral Disc Degeneration via the MAPK/Nrf2/HO-1 Pathway
by: Zhang C, et al.
Published: (2023)

Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway
by: Weikang Zhang, et al.
Published: (2022)

Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response [Corrigendum]
by: Zeng Q, et al.
Published: (2024)

Aucubin Alleviates Intervertebral Disc Degeneration by Repressing NF-κB-NLRP3 Inflammasome Activation in Endplate Chondrocytes
by: Zou K, et al.
Published: (2023)

Targeting Autophagy for Developing New Therapeutic Strategy in Intervertebral Disc Degeneration
by: Md Entaz Bahar, et al.
Published: (2022)

Yiqi Huoxue Recipe Delayed Intervertebral Disc Degeneration by Activating Autophagy
by: Feng Dai, et al.
Published: (2021)

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration
by: Jiongnan Xu, et al.
Published: (2023)

Genetic susceptibility of intervertebral disc degeneration among young Finnish adults
by: Kelempisioti Anthi, et al.
Published: (2011)

Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration
by: Umile Giuseppe Longo, et al.
Published: (2012)

The Pivotal Role of Nrf2 Signal Axis in Intervertebral Disc Degeneration
by: Pan C, et al.
Published: (2023)

The Upregulation of COX2 in Human Degenerated Nucleus Pulposus: The Association of Inflammation with Intervertebral Disc Degeneration
by: Chang Liu, et al.
Published: (2021)

Glutathione: A Key Regulator of Extracellular Matrix and Cell Death in Intervertebral Disc Degeneration
by: Fudong Li, et al.
Published: (2024)

PPAR γ/Nnat/NF-κB Axis Involved in Promoting Effects of Adiponectin on Preadipocyte Differentiation
by: Wenkai Yang, et al.
Published: (2019)

Magnoflorine Alleviates "M1" Polarized Macrophage-Induced Intervertebral Disc Degeneration Through Repressing the HMGB1/Myd88/NF-κB Pathway and NLRP3 Inflammasome
by: Feng Zhao, et al.
Published: (2021)