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Synergistic Antimicrobial Activity of Supplemented Medical-Grade Honey against <i>Pseudomonas aeruginosa</i> Biofilm Formation and Eradication

Biofilms hinder wound healing. Medical-grade honey (MGH) is a promising therapy because of its broad-spectrum antimicrobial activity and the lack of risk for resistance. This study investigated the inhibitory and eradicative activity against multidrug-resistant <i>Pseudomonas aeruginosa</i&...

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Main Authors: Carlos C. F. Pleeging (Author), Tom Coenye (Author), Dimitris Mossialos (Author), Hilde de Rooster (Author), Daniela Chrysostomou (Author), Frank A. D. T. G. Wagener (Author), Niels A. J. Cremers (Author)
Format: Book
Published: MDPI AG, 2020-12-01T00:00:00Z.
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Summary:Biofilms hinder wound healing. Medical-grade honey (MGH) is a promising therapy because of its broad-spectrum antimicrobial activity and the lack of risk for resistance. This study investigated the inhibitory and eradicative activity against multidrug-resistant <i>Pseudomonas aeruginosa</i> biofilms by different established MGH-based wound care formulations. Six different natural wound care products (Medihoney, Revamil, Mebo, Melladerm, L-Mesitran Ointment, and L-Mesitran Soft) were tested in vitro. Most of them contain MGH only, whereas some were supplemented. L-Mesitran Soft demonstrated the most potent antimicrobial activity (6.08-log inhibition and 3.18-log eradication). Other formulations ranged between 0.89-log and 4.80-log inhibition and 0.65-log and 1.66-log eradication. Therefore, the contribution of different ingredients of L-Mesitran Soft was investigated in more detail. The activity of the same batch of raw MGH (1.38-log inhibition and 2.35-log eradication), vitamins C and E (0.95-log inhibition and 0.94-log eradication), and all ingredients except MGH (1.69-log inhibition and 0.75-log eradication) clearly support a synergistic activity of components within the L-Mesitran Soft formulation. Several presented clinical cases illustrate its clinical antimicrobial efficacy against <i>Pseudomonas aeruginosa</i> biofilms. In conclusion, MGH is a potent treatment for <i>Pseudomonas</i> biofilms. L-Mesitran Soft has the strongest antimicrobial activity, which is likely due to the synergistic activity mediated by its supplements.
Item Description:10.3390/antibiotics9120866
2079-6382

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