Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

• Main Authors: Peiling Hu (Author), Ping Long (Author), Ruotong Li (Author), Xiaorong Lan (Author), Yuanpei He (Author), Guangwen Li (Author), Shiting Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionTissue repair can be promoted by moderate inflammation but suppressed by excessive levels. Therefore, control of excessive inflammation following removal of infection plays a critical role in promotion of pulpal repair. Connexin 43 (Cx43) forms hemichannels (HCs) or gap channels (GJs) to...