Cardiac stimulant activity of bark and wood of Premna serratifolia

Premna serratifolia Lin., (Verbenaceae) contains alkaloids and iridoid glycoside and is believed to prevent cardiovascular disease. The stem-bark and stem-wood were extracted with 95% ethanol and distilled water. These extracts were screened for their effects by Isolated Frog Heart Perfusion Techniq...

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Bibliographic Details
Main Authors: Saleem Basha N (Author), Rekha Rajendran (Author), Meenakshi Sundaram R (Author), Suseela L (Author)
Format: Book
Published: Bangladesh Pharmacological Society, 2008-12-01T00:00:00Z.
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001 doaj_5d7d0d4a5d8f4cd18ddc5bdd25d0ece5
042 |a dc 
100 1 0 |a Saleem Basha N  |e author 
700 1 0 |a Rekha Rajendran  |e author 
700 1 0 |a Meenakshi Sundaram R  |e author 
700 1 0 |a Suseela L  |e author 
245 0 0 |a Cardiac stimulant activity of bark and wood of Premna serratifolia 
260 |b Bangladesh Pharmacological Society,   |c 2008-12-01T00:00:00Z. 
500 |a 1991-007X 
500 |a 1991-0088 
520 |a Premna serratifolia Lin., (Verbenaceae) contains alkaloids and iridoid glycoside and is believed to prevent cardiovascular disease. The stem-bark and stem-wood were extracted with 95% ethanol and distilled water. These extracts were screened for their effects by Isolated Frog Heart Perfusion Technique and biochemical parameters in heart tissue and serum of albino rats after administering the extracts for 7 days. The ethanol extract produced significant positive ionotropic and negative chronotropic actions similar to that of digoxin on frog heart and its effect was inhibited by nifedipine and not by propranolol. A significant decrease in membrane Na+K+ATPase and Mg2+ATPase and an increase in Ca2+ATPase further confirmed its cardiotonic activity. Aqueous extract produced positive ionotropic and chronotropic effects similar to that of Adrenaline and its effect was antagonized by propranolol and nifedipine. The results suggest that the ethanol extract produced cardiotonic effect and the aqueous extract produced β-adrenergic effect. 
546 |a EN 
690 |a Adrenaline 
690 |a Cardiac stimulant 
690 |a Digoxin 
690 |a Premna serratifolia 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Bangladesh Journal of Pharmacology, Vol 3, Iss 2, Pp 107-113 (2008) 
787 0 |n http://www.bdjpharmacol.com/0302/107.pdf 
787 0 |n https://doaj.org/toc/1991-007X 
787 0 |n https://doaj.org/toc/1991-0088 
856 4 1 |u https://doaj.org/article/5d7d0d4a5d8f4cd18ddc5bdd25d0ece5  |z Connect to this object online.