Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer

• Main Authors: Siqi Yuan (Author), Dan She (Author), Shangming Jiang (Author), Nan Deng (Author), Jiayi Peng (Author), Ling Ma (Author)
• Format: Book
• Published: BMC, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER), due to genetic determinants and extrinsic environmental factors, leads to endoplasmic reticulum stress (ER stress). As ER stress ensues, the unfolded protein response (UPR), comprising three signaling...