Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity
<p>The protective effects of <em>Artemia salina</em> L. extract was examined against carbon tetrachloride (CCl<sub>4</sub>)-induced cell toxicity. In the <em>in vitro</em> model of study, markers such as cell viability, cellular reduced and oxidized glutathi...
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| Main Authors: | , , , , |
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| Format: | Book |
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Shiraz University of Medical Sciences,
2016-11-01T00:00:00Z.
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| Summary: | <p>The protective effects of <em>Artemia salina</em> L. extract was examined against carbon tetrachloride (CCl<sub>4</sub>)-induced cell toxicity. In the <em>in vitro</em> model of study, markers such as cell viability, cellular reduced and oxidized glutathione, and lipid peroxidation in HepG<sub>2</sub> cells was evaluated. Human liver cancer cell line HepG<sub>2 </sub>was treated with CCl<sub>4 </sub>and <em>Artemia salina</em> extract, and markers of hepatotoxicity were investigated. <em>Artemia salina</em> extract showed significant dose-dependent protective effects against the cytotoxicity of CCl4. This extract was able to normalize the levels of GSH, and thiobarbituric acid-reactive (TBARs), which were altered due to CCl4 intoxication in HepG2 cells. As the oxidative stress markers were ameliorated, it might be concluded that <em>Artemia salina</em> extract possesses protective effects probably due to its antioxidant constituents.</p> |
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| Item Description: | 2423-3722 2423-5652 10.1111/tips.v2i4.81 |