Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations

• Hlavní autoři: Grazyna Adler (Autor), Izabela Uzar (Autor), Amina Valjevac (Autor), Emina Kiseljakovic (Autor), Emir Mahmutbegovic (Autor), Nermin N. Salkic (Autor), Mateusz A. Adler (Autor), Nevena Mahmutbegovic (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2022-05-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Background CYP3A5 enzyme encoded by CYP3A5 is important for drug metabolism in gut and liver, whereas P-glycoprotein by ABCB1, is an ATP-dependent drug efflux pump which exports endo- and exogenous substances outside the cell. Aim The study was to assess the prevalence of CYP3A5 alleles: *1, *2, *3,...