Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations

• Autori principali: Grazyna Adler (Autore), Izabela Uzar (Autore), Amina Valjevac (Autore), Emina Kiseljakovic (Autore), Emir Mahmutbegovic (Autore), Nermin N. Salkic (Autore), Mateusz A. Adler (Autore), Nevena Mahmutbegovic (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2022-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background CYP3A5 enzyme encoded by CYP3A5 is important for drug metabolism in gut and liver, whereas P-glycoprotein by ABCB1, is an ATP-dependent drug efflux pump which exports endo- and exogenous substances outside the cell. Aim The study was to assess the prevalence of CYP3A5 alleles: *1, *2, *3,...