Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations

• Главные авторы: Grazyna Adler (Автор), Izabela Uzar (Автор), Amina Valjevac (Автор), Emina Kiseljakovic (Автор), Emir Mahmutbegovic (Автор), Nermin N. Salkic (Автор), Mateusz A. Adler (Автор), Nevena Mahmutbegovic (Автор)
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• Опубликовано: Taylor & Francis Group, 2022-05-01T00:00:00Z.
• Предметы: article
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Background CYP3A5 enzyme encoded by CYP3A5 is important for drug metabolism in gut and liver, whereas P-glycoprotein by ABCB1, is an ATP-dependent drug efflux pump which exports endo- and exogenous substances outside the cell. Aim The study was to assess the prevalence of CYP3A5 alleles: *1, *2, *3,...