The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis

• Main Authors: Kim Ohl (Author), Helge Nickel (Author), Halima Moncrieffe (Author), Patricia Klemm (Author), Anja Scheufen (Author), Dirk Föll (Author), Viktor Wixler (Author), Angela Schippers (Author), Norbert Wagner (Author), Lucy R. Wedderburn (Author), Klaus Tenbrock (Author)
• Format: Book
• Published: BMC, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Inflammatory effector T cells trigger inflammation despite increased numbers of Treg cells in the synovial joint of patients suffering from juvenile idiopathic arthritis (JIA). The cAMP response element (CREM)α is known to play a major role in regulation of T cells in SLE, coliti...