γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation
T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling. γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for allergic asthma. The aim of this study was to evalua...
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| Format: | Book |
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Hindawi Limited,
2015-01-01T00:00:00Z.
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| 001 | doaj_5e0e7efc3f744f09a86f8e7a692c6bbf | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Weixi Zhang |e author |
| 700 | 1 | 0 | |a Xueya Zhang |e author |
| 700 | 1 | 0 | |a Anqun Sheng |e author |
| 700 | 1 | 0 | |a Cuiye Weng |e author |
| 700 | 1 | 0 | |a Tingting Zhu |e author |
| 700 | 1 | 0 | |a Wei Zhao |e author |
| 700 | 1 | 0 | |a Changchong Li |e author |
| 245 | 0 | 0 | |a γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation |
| 260 | |b Hindawi Limited, |c 2015-01-01T00:00:00Z. | ||
| 500 | |a 0962-9351 | ||
| 500 | |a 1466-1861 | ||
| 500 | |a 10.1155/2015/258168 | ||
| 520 | |a T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling. γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for allergic asthma. The aim of this study was to evaluate the effect of GSI on Th17 cell differentiation in a mouse model of allergic asthma. OVA was used to induce mouse asthma model in the presence and absence of GSI. GSI ameliorated the development of OVA-induced asthma, including suppressing airway inflammation responses and reducing the severity of clinical signs. GSI also significantly suppressed Th17-cell responses in spleen and reduced IL-17 levels in serum. These findings suggest that GSI directly regulates Th17 responses through a Notch signaling-dependent pathway in mouse model of allergic asthma, supporting the notion that GSI is a potential therapeutic agent for the treatment of allergic asthma. | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Mediators of Inflammation, Vol 2015 (2015) | |
| 787 | 0 | |n http://dx.doi.org/10.1155/2015/258168 | |
| 787 | 0 | |n https://doaj.org/toc/0962-9351 | |
| 787 | 0 | |n https://doaj.org/toc/1466-1861 | |
| 856 | 4 | 1 | |u https://doaj.org/article/5e0e7efc3f744f09a86f8e7a692c6bbf |z Connect to this object online. |