EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes

• Main Authors: Xinyu Liu (Author), Conghui Li (Author), Jiao Li (Author), Lesi Xie (Author), Zeng Hong (Author), Kang Zheng (Author), Xiaofeng Zhao (Author), Aifen Yang (Author), Xiaofeng Xu (Author), Huaping Tao (Author), Mengsheng Qiu (Author), Junlin Yang (Author)
• Format: Book
• Published: BMC, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The conversion of astrocytes activated by nerve injuries to oligodendrocytes is not only beneficial to axonal remyelination, but also helpful for reversal of glial scar. Recent studies have shown that pathological niche promoted the Sox10-mediated astrocytic transdifferentiation...