Keratocystic odontogenic tumors related to Gorlin-Goltz syndrome: A clinicopathological study

• Main Authors: Mohammed Israr Ul Khaliq (Author), Ajaz A. Shah (Author), Irshad Ahmad (Author), Shahid Hasan (Author), Sagar S. Jangam (Author), Farah (Author), Anwar (Author)
• Format: Book
• Published: Elsevier, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: Assess clinicopathological features of patients with keratocystic odontogenic tumor (KCOT) associated with Gorlin-Goltz syndrome in our institution from 2004 to 2015. Method: After histopathological analyses of KCOT related to Gorlin-Goltz syndrome, 7 patients were assessed. These patients presented a total of 15 primary and 2 recurrent KCOT. Results: All patients presented a multiple KCOT, and 13 lesions were located in mandible (77%) and 4 (23%) in maxilla. Most of the tumors presented a unilocular pattern (71%) and had tooth association (88%). Four patients (57%) were in the age group of 10-19 years and three patients (43%) were in the age group of 20-29 years. There were four male and three female patients. Conclusion: KCOT is a frequent manifestation of Gorlin-Goltz syndrome and can be its first sign, mainly in young patients. The four patients presented with two lesions (57%) and three lesions in three patients (43%).

Item Description

2212-4268
10.1016/j.jobcr.2015.09.002